Tagsociety and culture

Cholesterol Levels

Esterides can cause in the child premature closing of epfisises, produce ginecomastia or cause flowery virilizao, as well as causing virilizao in the woman. At American gymnast you will find additional information. They can act on the heptica function, taking to colestase with increases of transaminases and bilirubins. This action depends on previous injury of the liver. Study in athlete with anablicos current and previous use of esterides, it found significant increase of transaminase oxaloactia (YOU), transaminase glutamicopirvica (TGP) and LDL HDL-cholesterol cholesterol and reduction. levels were modified in the athletes with current use of the drug, but none presented clinical manifestation.

The athletes who had made previous use had normal examinations, showing that the damage to hepatocelular is acute and ceases with the interruption of the drug. Esterides anablicos produces dramatical reduction of the HDL-cholesterol levels, and this reduction does not seem to become related with the dose, in view of that it can occur in therapeutical doses. The athletes in current use of esterides, can present lower HDL-cholesterol, showing bigger risk of ischemic illness (LABREE, 1991; WILSON, 1993). Estanozolol diminishes apolipoproteina and A-II THERE, while it increases apolipoproteina B and D. A probable involved mechanism is the induction of the activity of the HTLG- lipase triglicride endotelial heptica, a time that its levels increase 227 232% with estanozolol and 100% with oxandrolona.

This enzyme cataboliza HDL saw activity of fosfolipase and participates of hydrolysis of HDL2 for HDL3. The reduction of the HDL2 has greater relation with the coronariano risk. Research with comparisons evidences that it has reduction in the HDL-cholesterol, it occurs, however, reduction of the LDH, reduction of the levels of triglicrides and reduction of the total cholesterol. Although the reduction of the HDL, the concomitant reduction of the other lipdicas fractions, seem if comtrapor to the increase of the risk of coronariana illness.


The number of andrognicos receivers is under control of esterides gonadais, being that they had increased estrgenos them, whereas the andrgenos auto-they regulate its concentration, as observed in the elevating muscle of the anus (WILSON & GRIFFIN, 1993). The capacity of the muscle to answer to esteride anablico pparently is limited, probably to the point of the receiver to become saturated. However, the fact of doses supplies physiological of the hormone had still obtained to promote increase additional of the muscle, leads to believe in the existence of another mechanism, that not in level of the receiver. In this in case that, the possibility is an action of esteride anablico acting as antagonistic of glicocorticides, diminishing the protein degradation, what it would increase the proteinic synthesis. FORBES (1992) demonstrated to have relation dose-reply for esterides anablicos, with evident reply and high doses. Additionally, esterides anablicos can produce effect that is regulated by the central nervous system. Athletes in use of esterides are comumente more aggressive, they try little fatigue and they increase the intensity of the exercises. One gives credit that the number of the receivers of the muscle can increase through force training.

Programs of training of force combined with esteride anablico, could not only increase the small farms of receivers, but also the saturation of these receivers. This would result in increase of the proteinic synthesis and prevention of the protein in addition. For LAMB (1984), doubt regarding the effectiveness of esterides anablicos-andrognicos in promoting the protein synthesis does not exist in the esqueltico muscle and other fabrics, in some circumstances. In castrated rats these substances promote the nitrogen retention, increase of the lean mass and stimulate the muscular growth. Also they are very efficient in stimulating nitrogen retention and muscular development in men who have been castrated or are deficient of the natural hormone. Research with albumen marked human being (I 131 albumen) 15-N glicina, concluded that fenilpropionato of nandrolona directly speeds up the proteinic synthesis and the degree where this occurs, is related with the protein ingestion and calories (VAN WAYJEN, 1993).

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